Publications

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Publications - 2009-Present

68. Kasberg, W, Luong, P., Swift, K., Audhya, A., (2023) Nutrient deprivation alters the rate of COPII subunit recruitment at ER subdomains to tune secretory protein transport. Nature Communications. 14:8140

67. Salamon, R. J., Halbe, P., Kasberg, W., Bae J., Audhya, A., Mahmoud, A. I. (2023) Parasympathetic and sympathetic axons are bundled in the cardiac ventricles and undergo physiological reinnervation during heart regeneration, iScience. 26(10):107709

66. Kasberg W., Luong P., Hanna M.G., Minushkin K., Tsao A., Shankar R., Block S., Audhya A. (2023) The Sar1 GTPase is dispensable for COPII-dependent cargo export from the ER. Cell Rep. 42(6):112635

65. Paul S., Audhya A., Cui Q. (2023) Molecular mechanism of GTP binding- and dimerization-induced enhancement of Sar1-mediated membrane remodeling. Proc Natl Acad Sci. 120(8):e2212513120

64. Lynch AM, Zhu Y, Lucas BG, Winkelman JD, Bai K, Martin SCT, Block S, Slabodnick MM, Audhya A, Goldstein B, Pettitt J, Gardel ML, Hardin J. (2022) TES-1/Tes and ZYX-1/Zyxin protect junctional actin networks under tension during epidermal morphogenesis in the C. elegans embryo. Curr Biol. 32(23):5189-5199

63. Britigan EMC, Wan J, Sam DK, Copeland SE, Lasek AL, Hrycyniak LCF, Wang L, Audhya A, Burkard ME, Roopra A, Weaver BA. (2022) Increased Aurora B expression reduces substrate phosphorylation and induces chromosomal instability. Front Cell Dev Biol. 10:1018161

62. Clarke AL, Lettman MM, Audhya A. (2022) Lgd regulates ESCRT-III complex accumulation at multivesicular endosomes to control intralumenal vesicle formation. Mol Biol Cell. 33(14):ar144

61. Peotter, J.L., Pustova, I., Lettman, M.M., Shatadal, S., Bradberry, M.M., Winter-Reed, A.D., Charan, M., Sharkey, E.E., Alvin, J.R., Bren, A.M., Oie, A.K., Chapman, E.R., Salamat, S., Audhya, A., (2022) TFG regulates secretory and endosomal sorting pathways in neurons to promote their activity and maintenance. PNAS. 119(40):e2210649119

60. Zhang, R.R., Choi, C., Brunnquell, C.L., Hernandez, R., Pinchuk, A.N., Grudzinski, J.G., Clark, P.A., McMillan, A.B., Audhya, A., Jeffrey, J., Kuo, J.S., and Weichert, J.P. (2022) Next-generation cancer magnetic resonance imaging with tumor-targeted alkylphosphocholine metal analogs. Invest Radiol. 57: 655-663.

59. Shankar, R., Lettman, M.M., Whisler, W., Frankel, E.B., and Audhya, A.. (2022) The ESCRT machinery directs quality control over inner nuclear membrane architecture. Cell Rep. 38:110263.

58. Mandal, T., Spagnolie, S.E., Audhya, A., and Cui Q. (2021) Protein-induced membrane curvature in coarse-grained simulations. Biophys J. 2120:3211-3221.

57. Dieterich, I.A., Cui, Y., Braun, M.M., Lawton, A.J., Robinson, N.H., Peotter, J., Yu, Q., Casler, J.C., Glick, B.S., Audhya, A., Denu, J.M., Li, L., and Puglielli, L. (2021) Acetyl-CoA flux from the cytosol to the ER regulates engagement and quality of the secretory pathway. Sci. Rep. 11:2013.

56. Zhao, M., Zhang, F., Zarnowski, R., Barns, K.J., Jones, R., Fossen, J., Sanchez, H., Rajski, S.R., Audhya, A., Bugni, T.S., and Andes, D.R. (2020) Turbinmicin inhibits Candida biofilm growth by disrupting fungal vesicle-mediated trafficking. J. Clin. Invest. 131:e145123.

55. Zhang, F., Zhao, M., Braun, D.R., Ericksen, S.S., Piotrowski, J.S., Nelson, J., Peng, J., Ananiev, G.E., Chanana, S., Barns, K., Fossen, J., Sanchez, H., Chevrette, M.G., Guzei, I.A., Zhao, C., Guo, L., Tang, W., Currie, C.R., Rajski, S.R., Audhya, A., Andes, D.R., and Bugni, T.S. (2020) A marine microbiome antifungal targets urgent-threat drug-resistant fungi. Science. 370: 974-978.

54. Penfield, L., Shankar, R., Szentgyorgyi, E., Laffitte, A., Mauro, M., Audhya, A., Muller-Reichert, T., and Bahmanyar, S. (2020) Regulated lipid synthesis and LEM2/CHMP7 jointly control nuclear envelope closure. J. Cell Biol. 219: e201908179.

53. Mandal, T., Lough, W., Spagnolie, S.E., Audhya, A., and Cui, Q. (2020) Molecular simulation of mechanical properties and membrane activities of the ESCRT-III complexes. Biophys. J. 118: 1333-1343.

52. Block, S., Schuh, A.L., and Audhya, A. (2019) Biochemical Approaches to Studying Caenorhabditis elegans ESCRT Functions In Vitro. Methods Mol Biol. 1998: 189-202.

51. Peotter, J., Kasberg, W., Pustova, I., and Audhya, A. (2019) COPII‐mediated trafficking at the ER/ERGIC interface. Traffic. 20: 491-503.

50. Quinney, K., Frankel, E.B., Shankar, R., Kasberg, W., Luong, P., and Audhya, A. (2019) Growth factor stimulation promotes multivesicular endosome biogenesis by prolonging recruitment of the late-acting ESCRT machinery. Proc. Natl. Acad. Sci. USA. 116: 6858-6867.

49. Wan, J., Block, S., Scribano, C.M., Thiry, R., Esbona, K., Audhya, A., and Weaver, B.A. (2019) Mad1 destabilizes p53 by preventing PML from sequestering MDM2. Nat. Commun. 10: 1540.

48. Jones, J.R., Kong, L., Hanna, M.G., Hoffman, B., Krencik, R., Bradley, R., Hagemann, T., Choi, J., Doers, M., Dubovis, M., Sherafat, M.A., Bhattacharyya, A., Kendziorski, C., Audhya, A., Messing, A., and Zhang, S.C. (2018) Mutations in GFAP Disrupt the Distribution and Function of Organelles in Human Astrocytes. Cell Rep. 25: 947-958.

47. Slosarek, E.L.#, Schuh, A.L.#, Pustova, I.#, Johnson, A., Bird, J., Johnson, M., Frankel, E.B., Bhattacharya, N., Hanna, M.G., Burke, J.E., Ruhl, D.A., Quinney, K., Block, S., Peotter, J.L., Chapman, E.R., Sheets, M.D., Butcher, S.E., Stagg, S.M., and Audhya, A. (2018) Pathogenic TFG mutations underlying hereditary spastic paraplegia impair secretory protein trafficking and axon fasciculation. Cell Rep. 24: 2248-2260. (# denotes equal contribution)

46. Schenk, N.A., Dahl, P.J., Hanna, M.G., Audhya, A., Tall, G.G., Knight, J.D., and Anantharam, A. (2018) A simple supported tubulated bilayer system for evaluating protein-mediated membrane remodeling. Chem Phys Lipids. 215: 18-28.

45. Hanna, M.G., Peotter, J. L., Frankel, E.B., and Audhya, A. (2018) Membrane transport at an organelle interface in the early secretory pathway: Take your coat off and stay a while. BioEssays. e1800004.

44. Frankel, E.B. and Audhya, A. (2018) ESCRT-dependent cargo sorting at multivesicular endosomes. Semin Cell Dev Biol. 74:4-10. Link

43. Cox, N.J., Unlu, G., Bisnett, B.J., Meister, T.R., Condon, B., Luo, P.M., Smith, T.J., Hanna, M., Chhetri, A., Soderblom, E.J., Audhya, A., Knapik, E.W., and Boyce, M. (2018) Dynamic glycosylation governs the vertebrate COPII protein trafficking pathway. Biochemistry. 57: 91-107.

42. Frankel, E.B., Shankar, R., Moresco, J.J., Yates, J.R., Volkmann, N., and Audhya, A. (2017) Ist1 regulates ESCRT-III assembly and function during multivesicular endosome biogenesis in Caenorhabditis elegans embryos. Nat. Commun. 8: 1439. Link

41. Hanna, M.G., Block, S., Frankel, E.B., Hou, F., Johnson, A., Yuan, L., Knight, G., Moresco, J.J., Yates, J.R., Ashton, R., Schekman, R., Tong, Y., and Audhya, A. (2017) TFG facilitates outer coat disassembly on COPII transport carriers to promote tethering and fusion with ER-Golgi intermediate compartments. Proc. Natl. Acad. Sci. USA. 114: E7707-E7716. Link

40. Konig, J., Frankel, E.B., Audhya, A.*, and Muller-Reichert, T.* (2017) Membrane remodeling during embryonic abscission in Caenorhabditis elegans. J. Cell Biol. 216: 1277-1286. (* denotes co-corresponding authors) Link

39. Elsayed, L., Mohammed, I., Hamed, A., Elseed, M., Johnson, A., Mairey, M., Mohamed, H.E., Idris, M., Salih, M., Elsadig, S., Koko, M., Mohamed, A., Raymond, L., Coutelier, M., Darios, F., Siddig, R., Ahmed, A., Babai, A., Malik, H., Omer, Z., Mohamed, E., Eltahir, H., Magboul, N.A., Bushara, E., Elnour, A., Rahim, S.A., Alattaya, A., Elbashir, M., Ibrahim, M., Durr, A., Audhya, A., Ahmed, A., Stevanin, G., and Brice, A. (2017) Hereditary spastic paraplegias: Identification of a novel SPG57 variant affecting TFG oligomerization and description of HSP subtypes in Sudan. Eur. J. Hum. Genet. 25: 100-110. Link

38. Wang, L., Johnson, A., Hanna, M., and Audhya, A. (2016) Eps15 membrane binding and bending activity acts redundantly with Fcho1 during clathrin-mediated endocytosis. Mol. Biol. Cell. 27: 2676-2687. Link

37. Joo, J.H., Wang, B., Frankel, E., Ge, L., Xu, L., Iyengar, R., Li-Harms, X., Wright, C., Shaw, P.I., Lindsten, T., Green, D.R., Peng, J., Hendershot, L., Kilic, F., Sze, J.Y., Audhya, A., and Kundu, M. (2016) Non-Canonical Role of ULK/ATG1 in ER-to-Golgi Trafficking is Essential for Cellular Homeostasis. Mol. Cell. 62: 491-506. Link

36. Frankel, E.B., and Audhya, A. (2016) Burning cellular bridges: Two pathways to the big breakup. J. Cell Biol. 212: 491-493. Link

35. Hanna, M.G., Mela, I., Wang, L., Henderson, R.M., Chapman, E.R., Edwardson, J.M., and Audhya, A. (2016) Sar1 GTPase activity is regulated by membrane curvature. J. Biol. Chem. 291: 1014-1027. Link

34. Callaci, S., Morrison, K., Shao, X., Schuh, A.L., Wang, Y., Yates, J.R. 3rd, Hardin, J., and Audhya, A. (2015) Phosphoregulation of the C. elegans cadherin-catenin complex. Biochem. J. 472: 339-352. Link

33. Spear, J.M., Koborssy, D.A., Schwartz, A.B., Johnson, A.J., Audhya, A., Fadool, D.A., and Stagg, S.M. (2015) Kv1.3 contains an alternative C-terminal ER exit motif and is recruited into COPII vesicles by Sec24a. BMC Biochem. 16: 16. Link

32. Li, Z., Venegas, V., Nagaoka, Y., Morino, E., Raghavan, P., Audhya, A., Nakanishi, Y, and Zhou, Z. (2015) Necrotic cells actively attract phagocytes through the collaborative action of two distinct PS-exposure mechanisms. PLoS Genet. 11: e1005285. Link

31. Hwang, B., Phan, F.P., McCool, K., Choi, E.Y., You, J., Johnson, A., Audhya, A., and Miyamoto, S. (2015) Quantification of cellular NEMO content and its impact on NF-kB activation by genotoxic stress. PLoS One. 10: e0116374. Link

30. Schuh, A.L., Hanna, M., Quinney, K., Wang, L., Sarkeshik, A., Yates, J.R., and Audhya, A. (2015) The VPS-20 Subunit of the Endosomal Sorting Complex ESCRT-III Exhibits an Open Conformation in the Absence of Upstream Activation. Biochem J. 466: 625-637. Link

29. Johnson, A., Bhattacharya, N., Hanna, M., Pennington, J.G., Schuh, A.L., Wang, L., Otegui, M.S., Stagg, S.M., and Audhya, A. (2015) TFG clusters COPII-coated transport carriers and promotes early secretory pathway organization. EMBO J. 34: 811-827. Link

28. Takahashi, H., Mayers, J.R., Wang, L., Edwardson, J.M., and Audhya, A. (2015) Hrs and STAM function synergistically to bind ubiquitin-modified cargoes in vitro. Biophys. J. 108: 76-84. Link

27. Wan, J., Zhu, F., Zasadil, L., Yu, J., Wang, L., Johnson, A., Berthier, E., Beebe, D.J., Audhya, A., and Weaver, B.A. (2014) A Golgi localized pool of the mitotic checkpoint component Mad1 controls integrin secretion and cell migration. Curr. Biol. 24: 2687-2692. Link

26. Hsu, K.T., Yu, X.M., Audhya, A., Jaume, J.C., Lloyd, R.V., Miyamoto, S., Prolla, T.A., and Chen, H. (2014) Novel Approaches in Anaplastic Thyroid Cancer Therapy. Oncologist. 19: 1148-1155. Link

25. Shen, Q., Schuh, A.L. Zheng, Y., Quinney, K., Wang, L., Hanna, M., Mitchell, J.C., Otegui, M.S., Ahlquist, P., Cui, Q., and Audhya, A. (2014) Mechanisms governing ESCRT-III spiral filament assembly. J. Cell Biol. 206: 763-777. Link

24. Kebede, M., Oler, A., Balloon, A.J., Johnson, A., Rabaglia, M., Stapleton, D., Schueler, K., Floyd, B., Richards, O., Raines, S., Gregg, T., Eliceiri, K., Weisshaar J., Rhodes, C., Thorstenson, C., Keller, M.P., Coon, J., Audhya, A., and Attie, A.D. (2014) Sorcs1 is Required for Normal Dense Core Vesicle Biogenesis in Metabolically Stressed Beta-Cells. J. Clin. Invest. 124: 4240-4256. Link

23. Wang, L., and Audhya, A. (2014) In vivo imaging of C. elegans endocytosis. Methods. 68: 518-528. Link

22. Wickert, L.E., Karta, M.R., Audhya, A., Gern, J.E., and Bertics, P.J. (2014) Simvastatin attenuates rhinovirus-induced interferon and CXCL10 secretion from monocytic cells in vitro. J. Leukoc. Biol. 95: 951-959. Link

21. Schuh, A.L., and Audhya, A. (2014) The ESCRT machinery: From the plasma membrane to endosomes and back again. Crit. Rev. Biochem. Mol. Biol. 49: 242-261. Link

20. Bahmanyar, S., Biggs, R., Schuh, A.L., Desai, A., Müller-Reichert, T., Audhya, A., Dixon, J.E., and Oegema, K. (2014) Spatial control of phospholipid flux restricts endoplasmic reticulum sheet formation to allow nuclear envelope breakdown. Genes Dev. 28: 121-126. Link

19. Green, R., Mayers, J.R., Lewellyn, L., Desai, A., Audhya, A., and Oegema, K. (2013) The midbody ring scaffolds abscission in the absence of midbody microtubules in the C. elegans embryo. J. Cell Biol. 203: 505-520. Link

18. Mayers, J.R., Wang, L., Pramanik, J., Johnson, A., Wang, Y., Sarkeshik, A., Saengsawang, W., Yates, J.R., and Audhya, A. (2013) Regulation of ubiquitin-dependent cargo sorting by multiple endocytic adaptors at the plasma membrane. Proc. Natl. Acad. Sci. USA. 110: 11857-11862. Link

17. Beetz, C., Johnson, A., Schuh, A., Thakur, S., Varga, R., Fothergill, T., Hertel, N., Bomba-Warczak, E., Thiele, H., Nurnberg, G., Altmuller, J., Saxena, R., Chapman, E.R., Dent, E.W., Nurnberg, P., and Audhya, A. (2013) Inhibition of TFG function causes hereditary axon degeneration by impairing ER structure. Proc. Natl. Acad. Sci. USA. 110: 5091-5096. Link

16. Hanna, M., Wang, L., and Audhya, A. (2013) Worming our way in and out of the C. elegans germline and developing embryo. Traffic. 14: 471-478. Link

15. Morrison, K., Witte, K., Mayers, J.R., Schuh, A.L., and Audhya, A. (2012) Role of acidic phospholipids and nucleotides in regulating membrane binding and activity of a calcium-independent phospholipase A2 isoform. J. Biol. Chem. 287: 38824-38834. Link

14. Ryan, S.D., Britigan, E.M., Zasadil, L.M., Witte, K., Audhya, A., Roopra, A., and Weaver, B.A. (2012) Up-regulation of the mitotic checkpoint component Mad1 causes chromosomal instability and resistance to microtubule poisons. Proc. Natl. Acad. Sci. USA. 109: E2205-E2214. Link

13. Ling, Y., Stefan, C.J., MacGurn, J.A., Audhya, A., and Emr, S.D. (2012) The dual PH domain protein Opy1 functions as a sensor and modulator of PtdIns(4,5)P2 synthesis. EMBO J. 31: 2882-2894. Link

12. Joseph-Strauss, D., Gorjanacz, M., Santarella-Mellwig, R., Voronina, E., Audhya, A., and Cohen-Fix, O. (2012) Sm protein down-regulation leads to defects in nuclear pore complex disassembly and distribution in C. elegans embryos. Dev. Biol. 15: 445-457. Link

11. Mayers, J.R., and Audhya, A. (2012) Vesicle formation within endosomes: An ESCRT marks the spot. Commun. Integr. Biol. 5: 50-56. Link

10. Schuh, A.L., and Audhya, A. (2012) Phosphoinositide signaling during membrane transport in Saccharomyces cerevisiae. Subcell. Biochem. 59: 35-63. Link

9. Fyfe, I., # Schuh, A.L., # Edwardson, J.M., and Audhya, A. (2011) Association of the endosomal sorting complex ESCRT-II with the Vps20 subunit of ESCRT-III generates a curvature sensitive protein complex capable of nucleating filaments of ESCRT-III. J. Biol. Chem. 286: 34262-34270. Link (# denotes equal contribution)

8. Park, S., Patterson, E.E., Cobb, J., Audhya, A., Gartenberg, M.R., and Fox, C.A. (2011) Palmitoylation controls the dynamics of budding yeast heterochromatin via the telomere-binding protein Rif1. Proc. Natl. Acad. Sci. USA. 108: 14572-14577. Link

7. Witte, K., Schuh, A.L., Hegermann, J., Sarkeshik, A., Mayers, J.R., Schwarze, K., Yates, J.R., Eimer, S., and Audhya, A. (2011) TFG-1 function in protein secretion and oncogenesis. Nat. Cell Biol. 13: 550-558. Link

6. Green, R., Kao, H.,# Audhya, A.,# Arur, S., Mayers, J.R., Fridolfsson, H., Schulman, M., Schloissnig, S., Niessen, S., Laband, K., Wang, S., Starr, D., Hyman, A., Schedl, T., Desai, A., Piano, F., Gunsalus, K.C., and Oegema, K. (2011) A high-resolution C. elegans essential gene network based on phenotypic profiling of a complex tissue. Cell. 145: 470-482. Link (# denotes equal contribution)

5. Mayers, J.R., Fyfe, I., Schuh, A.L., Chapman, E.R., Edwardson, J.M., and Audhya, A. (2011) ESCRT-0 assembles as a heterotetrameric complex on membranes and binds multiple ubiquitinylated cargoes simultaneously. J. Biol. Chem. 286: 9636-9645. Link

4. Zaidel-Bar, R., Joyce, M.J., Lynch, A.M., Witte, K., Audhya, A., and Hardin, J. (2010). The F-BAR domain of SRGP-1 facilitates cell-cell adhesion during C. elegans morphogensis. J. Cell Biol. 191: 761-769. Link

3. Shi, A., Chen, C.C., Banerjee, R., Glodowski, D., Audhya, A., Rongo, C., and Grant, B.D. (2010). EHBP-1 functions with RAB-10 during endocytic recycling in C. elegans. Mol. Biol. Cell. 21: 2930-2943. Link

2. Ziel, J.W., Hagedorn, E.J., Audhya, A., and Sherwood, D.R. (2009). UNC-6 (Netrin) orients the invasive membrane of the anchor cell in C. elegans. Nat. Cell Biol. 11: 183-189. Link

1. Rodenas, E., Klerkx, E.P., Ayuso, C., Audhya, A., and Askjaer, P. (2009). Early embryonic requirement for nucleoporin Nup35/NPP-19 in nuclear assembly. Dev. Biol. 327: 399-409. Link

Publications - 2005-2008

1. Audhya, A., Hyndman, F., McLeod, I.X., Maddox, A.S., Yates, J.R. III, Desai, A., and Oegema, K. (2005). A complex containing the Sm protein CAR-1 and the RNA helicase CGH-1 is required for embryonic cytokinesis in Caenorhabditis elegans. J. Cell Biol. 171: 267-279.Link

2. Grant, B.D., and Audhya, A. (2005). The ins and outs of endocytic transport. Nat. Cell Biol. 7: 1051-1054. Link

3. Sato, K., Sato M., Audhya, A., Oegema, K., Schweinsberg, P., and Grant, B.D. (2006). Dynamic regulation of Caveolin-1 trafficking in the germ line and embryo of Caenorhabditis elegans. Mol. Biol. Cell. 17: 3085-3094.Link

4. Tabuchi, M., Audhya, A., Parsons, A.B., Boone, C., and Emr, S.D. (2006). The PI4,5P2 and TORC2 binding proteins, Slm1 and Slm2, function in sphingolipid regulation. Mol. Cell. Biol. 26: 5861-5875.Link

5. McNally, K., Audhya, A., Oegema, K., and McNally, F.J. (2006). Katanin controls mitotic and meiotic spindle length. J. Cell Biol. 175: 881-891.Link

6. Portier, N., Audhya, A., Maddox, P.S., Green, R.A., Dammermann, A., Desai, A., and Oegema, K. (2007). A microtubule-independent role for centrosomes and Aurora A in nuclear envelope breakdown. Dev. Cell. 12: 515-529.Link

7. Audhya, A., Desai, A., and Oegema, K. (2007a). A role for Rab5 in ER structure and nuclear envelope disassembly. J. Cell Biol. 178: 43-56.Link

8. Audhya, A., McLeod, I.X., Yates, J.R. III, and Oegema, K. (2007b). MVB-12, a Fourth Subunit of Metazoan ESCRT-I, Functions in Receptor Downregulation. PLoS ONE. 2: e956.Link

9. Green, R.A., Audhya, A., Pozniakovsky, A., Dammermann, A., Pemble, H., Monen, J., Portier, N., Hyman, A., Desai, A., and Oegema, K. (2008). Expression and imaging of fluorescent proteins in the C. elegans gonad and early embryo. Methods Cell Biol. 85: 179-218.Link

10. Kachur, T.M., Audhya, A., and Pilgrim D.B. (2008). UNC-45 is required for NMY-2 contractile function in early embryonic polarity establishment and germline cellularization in C. elegans. Dev. Biol. 314: 287-299.Link

11. Audhya, A., and Desai, A. (2008). Proteomics in Caenorhabditis elegans. Brief. Funct. Genomic. Proteomic. 7: 205-210.Link

12. Baird, D., Stefan, C.J., Audhya, A., Weys, S., and Emr, S.D. (2008). Assembly of the PtdIns 4-kinase Stt4 complex at the plasma membrane requires Ypp1 and Efr3. J. Cell Biol. 183: 1061-1074.Link

Publications - 2000-2005

1. Audhya, A., Foti, M., and, Emr S.D. (2000). Distinct roles for the yeast PtdIns 4 – kinases, Stt4p and Pik1p, in secretion, cell growth and organelle membrane dynamics. Mol. Biol. Cell 11: 2673 – 2689. Link

2. Foti, M., Audhya, A., and Emr, S.D. (2001). Sac1 lipid phosphatase and Stt4 phosphatidylinositol 4 – kinase regulate a pool of phosphatidylinositol 4 – phosphate that functions in the control of the actin cytoskeleton and vacuole morphology. Mol. Biol. Cell 12: 2396 – 2411.Link

3. Stefan, C.J., Audhya, A., and Emr, S.D. (2002). The yeast synaptojanin – like proteins control the cellular distribution of phosphatidylinositol (4,5) – bisphosphate. Mol. Biol. Cell 13: 542 – 557. Link

4. Audhya, A., and Emr, S.D. (2002). Stt4 PI 4 – kinase localizes to the plasma membrane and functions in the Pkc1 – mediated MAP kinase cascade. Dev. Cell 2: 593 – 605. Link

5. Han, G.S., Audhya, A., Markley, D.J., Emr, S.D., and Carman, G.M. (2002). The Saccharomyces cerevisiae LSB6 gene encodes PI 4 – kinase activity. J. Biol. Chem. 277: 47709 – 47718.Link

6. Audhya, A., and Emr, S.D. (2003). Regulation of PI4,5P2 synthesis by nuclear – cytoplasmic shuttling of the Mss4 lipid kinase. EMBO J. 22: 4223 – 4236. Link

7. Odorizzi, G., Katzmann, D.J., Babst, M., Audhya, A., and Emr, S.D. (2003). Bro1 is an endosome – associated class E Vps protein that functions in the MVB – sorting pathway in Saccharomyces cerevisiae. J. Cell Sci. 115: 1893 – 1903.Link

8. Stefan, C.J., Audhya, A., and Emr, S.D. (2003). FYVE domains in membrane trafficking and cell signaling. Handbook for Cell Signaling. 2: 177 – 185.

9. Katzmann, D.J., Sarkar, S., Chu, T., Audhya, A., and Emr, S.D. (2004). Multivesicular Body Sorting: Ubiquitin ligase Rsp5 is required for the modification and sorting of Carboxypeptidase S. Mol. Biol. Cell. 15: 468 – 480.Link

10. Yu, J.W., Mendrola, J.M., Audhya, A., Keleti, D., Dewald, D., Emr, S.D., and Lemmon, M.A. (2004). Genome – wide analysis of PH domain function in Saccharomyces cerevisiae. Mol. Cell. 13: 677 – 688. Link

11. Miller, A.L., Suntharalingam, M., Johnson, S.L., Audhya, A., Emr, S.D., and Wente, S.R. (2004). Cytoplasmic IP6 production is sufficient for mediating the Gle1 – mRNA export pathway. J. Biol. Chem. 273: 51022 – 51032.Link

12. Audhya, A., Loewith, R., Parsons, A.B., Gao, L., Tabuchi, M., Zhao, H., Boone, C., Hall, M.N., and Emr, S.D. (2004). Genome – wide lethality screen identifies new PI4,5P2 effectors that regulate the actin cytoskeleton. EMBO J. 23: 3747 – 3757.Link

13. Sciorra, V.A., Audhya, A., Parsons, A.B., Segev, N., Boone, C., and Emr, S.D. (2005). Synthetic genetic array analysis of the PtdIns 4 – kinase Pik1p identifies components in a Golgi – specific Ypt31/rab – GTPase signaling pathway. Mol. Biol. Cell. 16: 776 – 793.Link

14. Stefan, C.J., Padilla, S.M., Audhya, A., and Emr, S.D. (2005). The phosphoinositide phosphatase Sjl2 is recruited to cortical actin patches in the control of vesicle formation and fission. Mol. Cell. Biol. 25: 2910 – 2923. Link